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Therapeutics

Review: Acellular vaccines prevent pertussis as effectively as whole-cell vaccines with fewer adverse events

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ACP J Club. 2000 Jan-Feb;132:27. doi:10.7326/ACPJC-2000-132-1-027


Source Citation

Tinnion ON. Acellular vaccines for preventing whooping cough in children. Cochrane Review, latest version 24 Feb 1999. In: The Cochrane Library. Oxford: Update Software. [PubMed ID: 20257738]


Abstract

Question

In children ≤ 6 years of age, how well do acellular vaccines (compared with whole-cell vaccines) protect against pertussis disease (whooping cough)?

Data sources

Studies were identified using MEDLINE (1966 to 1997) and the Cochrane Controlled Trials Register.

Study selection

Studies were selected if they were randomized, double-blind, controlled trials of the efficacy or safety of acellular pertussis vaccines. Efficacy studies had to have active follow-up of participants and laboratory confirmation of pertussis.

Data extraction

Data were extracted on study quality, case definition (whooping cough or pertussis disease), immunization schedule and vaccine characteristics, efficacy results (absolute or relative efficacy), and adverse events.

Main results

45 studies were included; all 45 addressed safety, and 6 studies addressed efficacy. 4 efficacy trials included placebo or diphtheria toxoid (DT) as the control therapy and thus permitted calculation of absolute efficacy: Acellular vaccines were more efficacious than placebo or DT in preventing whooping cough (absolute efficacy range 36% to 85%); 3 of the 4 trials showed greater efficacy of acellular vaccines in preventing pertussis disease (absolute efficacy range 23% to 78%). Acellular vaccines with ≥ 3 components were more efficacious than vaccines with 1 to 2 components. 4 trials directly compared acellular vaccines with whole-cell vaccines. The acellular vaccines were relatively more efficacious than 1 type of whole-cell vaccine but less efficacious than 2 other types of whole-cell vaccine in preventing whooping cough. For most safety outcomes, including death from all causes and death from infection, acellular vaccine and whole-cell vaccines did not differ. 8 of 9 minor adverse events—anorexia, fever, irritability, prolonged crying, vomiting, pain or tenderness, redness, and swelling or induration—were reduced with acellular vaccines; drowsiness was not reduced. Noncompletion of the primary series because of adverse effects was reduced in recipients of acellular vaccines (Table).

Conclusion

Acellular pertussis vaccines are efficacious in preventing pertussis disease (whooping cough) in children ≤ 6 years of age and are associated with fewer adverse events than whole-cell vaccines.

Source of funding: No external funding.

For correspondence: Dr. O. Tinnion, Master of Population Health Program, National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory 0200, Australia. FAX 61-2-6249-0740.


Table. Acellular vaccines vs whole-cell vaccines for preventing whooping cough (follow-up range 1 d to 28 mo)*

Outcome Number of studies Weighted event rates RRR (95% CI) NNT (CI)
Acellular Whole cell
Noncompletion of primary series 14 0.37% 1.17% 72% (67 to 76) 125 (111 to 143)

*Abbreviations defined in Glossary; RRR, NNT, and CI calculated from data in article.


Revised Commentary 2006

Acellular pertussis vaccines were developed because of concerns about adverse effects of whole-cell pertussis vaccines. The review by Tinnion addresses clinically important questions relating to the efficacy (protection against pertussis disease in vaccinated persons) and safety of these vaccines. It does not address vaccine effectiveness (effect on levels of disease in the community when the vaccine is introduced), which is affected by other factors, including vaccine uptake rates and herd immunity.

In fact, recent evidence from clinical trial evidence shows that the acellular pertusiss vaccine is protective among adolescents and adults and, if used routinely, could reduce the overall burden and transmission to children (1).

Assessing acellular vaccine efficacy has been complicated by substantial differences among acellular vaccines (those using ≥ 3 pertussis components seem to be more efficacious than those with 1 to 2 components) and whole-cell vaccines (2). These differences, combined with schedule variations, precluded a meta-analysis of the efficacy trials. The best acellular vaccines approach the efficacy of the best whole-cell vaccines.

Safety is easier to address for common adverse events. To prevent 1 additional fever of 38° C from a whole-cell vaccine, the number needed to treat (vaccinate) with acellular vaccines is 4. For convulsions and hypotonic or hyporesponsive episodes, the relative reduction with acellular vaccines is statistically significant. The absolute difference is small, however, because of the rarity of these events, with differences of only 6 per 10 000 primary courses both for convulsions and for hypotonic or hyporesponsive episodes.

National choice of vaccine type will be influenced by local rates of disease and death from pertussis, schedule timing, vaccine uptake rates, public acceptance of adverse events, and available funds. In developing countries, where the incidence of pertussis is high, acellular vaccines at a cost > U.S. $10 per dose are probably a less viable option than improving coverage with whole-cell vaccines, which cost only a few cents per dose.

Jim Buttery, MBBS
John Radcliffe Hospital
Oxford, England, United Kingdom


Revised References 2006

1. Ward JI, Cherry JD, Chang SJ, et al., for the APERT Study Group Efficacy of an acellular pertussis vaccine among adolescents and adults. N Engl J Med. 2005;353:1555-63. [PubMed ID: 16221778]

2. Greco D, Salmaso S, Mastrantonio P, et al. A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group. N Engl J Med. 1996;334:341-8. [PubMed ID: 8538704]