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Therapeutics

Transcervical resection of the endometrium was effective and acceptable at up to 2 years for heavy menstrual bleeding

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ACP J Club. 2000 Jan-Feb;132:28. doi:10.7326/ACPJC-2000-132-1-028


Source Citation

Cooper KG, Parkin DE, Garratt AM, Grant AM. Two-year follow up of women randomised to medical management or transcervical resection of the endometrium for heavy menstrual loss: clinical and quality of life outcomes. Br J Obstet Gynaecol. 1999 Mar;106:258-65. [PubMed ID: 10426646]


Abstract

Question

In women with heavy menstrual bleeding, is transcervical resection of the endometrium (TCRE) better than medical management for relieving menstrual symptoms in the long term?

Design

Randomized {concealed*}†, unblinded,* controlled trial with 2-year follow-up.

Setting

Gynecology department of a large hospital in Scotland, United Kingdom.

Patients

187 women who consulted a gynecologist for the first time for heavy menstrual bleeding, were not going to have more children, had a clinical diagnosis of dysfunctional uterine bleeding, had not been referred for surgery, and did not have a treatment preference. Follow-up was 93% (mean age 42 y).

Intervention

Women were allocated to TCRE (n = 93) or medical management (n = 94). Medical management consisted of progestogens, combined oral contraceptive pill, tranexamic acid, danazol, or hormone replacement therapy and nonsteroidal anti-inflammatory drugs.

Main outcome measures

Gynecologic symptoms, patient satisfaction, acceptability of treatment, and additional treatments were assessed by a mailed questionnaire. The hospital surgical database also provided data on additional treatments. Changes in health-related quality of life were assessed by the Short Form (SF)-36 health survey.

Main results

Analysis was by intention to treat. At 2 years, fewer women in the TCRE group than in the medical management group had unchanged or heavier menstrual bleeding (P = 0.02) or required additional treatments {P < 0.001}‡ (Table). 51 of 68 (75%) women in the medical-management group and 15 of 22 (68%) women in the TCRE group who needed additional treatment had surgery. More women in the TCRE group than in the medical management group were satisfied with their treatment (P = 0.002), were cured or had an acceptable improvement in their symptoms (P = 0.017), and rated their treatment as acceptable (P = 0.004) (Table). Women in the TCRE group had improvement in 7 of 8 SF-36 health scores, and women in the medical-management group had improvement in 5 of 8 SF-36 health scores.

Conclusion

In women with heavy menstrual bleeding, transcervical resection of the endometrium was better than medical management for patient satisfaction and symptom relief.

*See Glossary.

Cooper KG, Parkin DE, Garratt AM, Grant AM. Br J Obstet Gynaecol. 1997;104:1360-6.

P value calculated from data in article.

Source of funding: Scottish Office Department of Health.

For correspondence: Dr. K.G. Cooper, Department of Obstetrics and Gynaecology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZB, Scotland, UK.


Table. Transcervical resection of the endometrium (TCRE) vs medical management for heavy menstrual bleeding§

Outcomes at 2 y TCRE Medical care RRR (95% CI) NNT (CI)
Unchanged or increased bleeding 6% 19% 69% (23 to 88) 8 (5 to 31)
Needed additional treatment 25% 79% 68% (54 to 78) 2 (2 to 3)
RBI (CI)
Totally or generally satisfied 78% 56% 40% (13 to 76) 5 (3 to 12)
Cure or acceptable improvement 79% 62% 29% (6 to 59) 6 (4 to 25)
Treatment acceptable 91% 76% 20% (5 to 40) 7 (4 to 24)

§Abbreviations defined in Glossary; RRR, RBI, NNT, and CI calculated from data in article.


Commentary

The application of evidence-based gynecology is necessary, but randomized trials in ambulatory surgery are not easy to do. Cooper and colleagues deserve our congratulations.

2 years after TCRE, 9 of every 10 patients still found this procedure acceptable, and 3 of every 4 women required no additional surgical or medical treatment after their TCRE operation. Thus, having a TCRE reduced the chances of having a hysterectomy the following year, which is the major practice recommendation and point of this paper.

Not so comforting is the disease that the authors were treating in these patients. Heavy menstrual loss is a symptom, not a diagnosis. Dysfunctional uterine bleeding it might be, but the mean hemoglobin concentration was 12.6 g/dL. I will admit to bias of being a “measurer,” but I wish the authors had used objective entry criteria for their study. We read more than once that this was a “pragmatic trial,” but what is more pragmatic than making a clinical diagnosis?

85 of 272 (31%) eligible patients did not consent to randomization. Were they more satisfied after 2 years than were the randomized patients?

I believe the authors have shown that early TCRE is an acceptable and effective ambulatory surgical alternative to hysterectomy. However, is it cost-effective? Almost 4 of every 5 women in the medical management group found their treatments acceptable, and medical treatment may still be less expensive and effective enough as the first choice of treatment. A cost-effectiveness study should be the next step in this research.

David Healy, MBBS, PhD
Monash University
Melbourne, Victoria, Australia