A normal-calcium, low-protein, low-salt diet reduced recurrence of renal stones over 5 years
ACP Journal Club. 2002 Sep-Oct;137:62.
Borghi L, Schianchi T, Meschi T, et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med. 2002 Jan 10;346:77-84. [PubMed ID: 11784873] (All 2002 articles were reviewed for relevancy, and abstracts were last revised in 2008.)
In men with recurrent calcium oxalate stones and hypercalciuria, is a diet containing a normal amount of calcium but reduced amounts of animal protein and salt more effective than a traditional low-calcium diet?
Randomized (unclear allocation concealment*), blinded (outcome assessors),* controlled trial with 5-year follow-up.
An outpatient department in Parma, Italy.
120 men (mean age 45 y) who had idiopathic hypercalciuria (urinary calcium excretion > 300 mg/d) on an unrestricted diet, recurrent formation of calcium oxalate stones ( 2 colic episodes with expulsion of stones or radiographic evidence of retained stones), no known condition commonly associated with calcium nephrolithiasis, no previous visit to a stone disease center, and no current treatment for prevention of recurrent stones. 103 men (86%) completed the study (13 withdrew, 2 were lost to follow-up, and 2 died).
60 men were allocated to a normal-calcium (30 mmol/d), low-animal-protein (52 g/d), low-salt (50 mmol/d) diet (intervention diet). They were given detailed written explanations to help them comply with the diet. 60 men were allocated to a low-calcium diet and instructed to avoid milk, yogurt, and cheese so that calcium intake would be reduced to 10 mmol/d. Both groups were advised to avoid large quantities of oxalate-rich foods (e.g., walnuts, spinach, and chocolate) and to drink 2 to 3 liters of water/d.
Main outcome measure
First recurrence of a symptomatic renal stone or presence of a radiographically identified stone.
Analysis was by intention to treat. Kaplan-Meier analysis showed that over 5 years, men who received the intervention diet were less likely to have a recurrence of stones than were men who received the low-calcium diet (Table).
In men with recurrent calcium oxalate stones and hypercalciuria, a normal-calcium, low-animal-protein, low-salt diet reduced the risk for recurrent stones more than did a traditional low-calcium diet over 5 years.
Sources of funding: University of Parma and Italian Ministry for Universities and for Scientific and Technological Research.
For correspondence: Dr. L Borghi, University of Parma, Parma, Italy. E-mail firstname.lastname@example.org.
Normal-calcium, low-protein, low-salt (intervention) diet vs a low-calcium diet for men with hypercalciuria at 5 years (unadjusted analysis)†
†Abbreviations defined in Glossary; RRR, NNT, and CI calculated from point estimates reported in article.
Calcium oxalate kidney stones are common, costly, painful, and preventable. Dietary modification, particularly calcium restriction, has been a hallmark of prevention but has never been shown to be beneficial. Observational studies in the mid-1990s found that a higher dietary calcium intake was associated with a reduced risk for incident stone formation (1, 2). However, the question remained whether increasing dietary calcium would reduce the risk for recurrent stone formation, particularly in individuals with hypercalciuria.
The seminal trial by Borghi and colleagues showed that a normal-to-high calcium, low-sodium, low-animal-protein diet reduced the risk for stone recurrence in patients with hypercalciuria. Notably, urinary calcium actually decreased in the intervention group, probably because of the substantial reduction in sodium and animal protein intake. The relatively low dropout rate and high compliance are encouraging. One note of caution is that the mean baseline urinary calcium levels were high (> 400 mg/d), even for patients with recurrent stones.
Two clinically relevant applications of these findings emerge. First and most important, dietary calcium restriction in patients with hypercalciuria can lead to a negative calcium balance and decreased bone mineral density. Second, relatively simple dietary modifications can lead to beneficial changes in urine composition and reduce the likelihood of stone recurrence.
Several questions remain to be answered. Is dietary modification as effective in patients with less extreme urinary values? What are the relative contributions of higher calcium, lower animal protein, and lower sodium to reduced stone recurrence? For patients who prefer to avoid dairy products (the major source of dietary calcium), do calcium supplements work as well if taken at mealtime? Can this dietary approach also reduce the risk for recurrence in patients with calcium phosphate stones?
Patients and providers should be aware of this evidence supporting the benefits of dietary and fluid modifications to prevent stone recurrence. Physicians should stop restricting calcium intake.
Gary Curhan, MD, ScD
Harvard Medical School
Boston, Massachusetts, USA
1. Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med. 1993;328:833-8. [PubMed ID: 8441427]
2. Curhan GC, Willett WC, Speizer FE, Spiegelman D, Stampfer MJ. Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women. Ann Intern Med. 1997;126:497-504. [PubMed ID: 9092314]
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