Review: Medical history, physical examination, and routine tests are useful for diagnosing heart failure in dyspneaPDF
ACP J Club. 2006 Mar-Apr;144:49. doi:10.7326/ACPJC-2006-144-2-049
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• Letter: Review: Medical history, physical examination, and routine tests are useful for diagnosing heart failure in dyspnea
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Wang CS, FitzGerald JM, Schulzer M, Mak E, Ayas NT. Does this dyspneic patient in the emergency department have congestive heart failure? JAMA. 2005;294:1944-56. [PubMed ID: 16234501]
In patients presenting to the emergency department (ED) with dyspnea, how useful are medical history, physical examination, and readily available tests in diagnosing heart failure (HF)?
Data sources: MEDLINE (1966 to July 2005) and reference lists of relevant articles and textbooks.
Study selection and assessment: English language studies that assessed the diagnostic accuracy of elements of the history, physical examination, or readily available tests in adults with undifferentiated dyspnea presenting to the ED. The reference standard was diagnosis by a panel of physicians based on clinical signs and symptoms and an appropriate measure of cardiac dysfunction. 2 reviewers independently assessed the studies for inclusion and methodological quality.
Outcomes: Pooled positive and negative likelihood ratios (LRs) for HF, calculated using a random-effects model.
22 studies met the selection criteria, but only 18 high-quality studies were included. Features assessed in > 1 study and found to be useful in diagnosing HF are in the Table.
In adults presenting to the emergency department with dyspnea, findings useful in ruling in heart failure include, in decreasing order, pulmonary venous congestion, interstitial edema, third heart sound, history of HF, and jugular venous distention. Findings useful in ruling out HF include, in decreasing order, a serum B-type natriuretic peptide test < 100 pg/mL and the absence of cardiomegaly, pulmonary venous congestion, rales, dyspnea on exertion, and history of HF.
Source of funding: No external funding.
For correspondence: Dr. N.T. Ayas, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada. E-mail firstname.lastname@example.org.
Table. Elements of clinical examination and routine diagnostic tests that were useful in diagnosing heart failure*
|Diagnostic tests||Findings||Number of studies||Pooled sensitivity||Pooled specificity||Pooled +LR||Pooled −LR|
|History||Heart failure Myocardial infarction Coronary artery disease||7 6 4||60% 40% 52%||90% 87% 70%||5.8 3.1 1.8||0.45 0.69 0.68|
|Symptoms||Paroxysmal nocturnal dyspnea Orthopnea Dyspnea on exertion||5 8 2||41% 50% 84%||84% 77% 34%||2.6 2.2 1.3||0.70 0.65 0.48|
|Physical examination||Third heart sound Jugular venous distention Rales Any murmur Lower extremity edema Wheezing||8 8 8 4 6 5||13% 39% 60% 27% 50% 22%||99% 92% 78% 90% 78% 58%||11 5.1 2.8 2.6 2.3 0.52||0.88 0.66 0.51 0.81 0.64 1.3|
|Chest radiograph||Pulmonary venous congestion Interstitial edema Cardiomegaly Pleural effusion||4 2 6 2||54% 34% 74% 26%||96% 97% 78% 92%||12 12 3.3 3.2||0.48 0.68 0.33 0.81|
|Electrocardiogram||Atrial fibrillation Any abnormal finding||5 2||26% 50%||93% 78%||3.8 2.2||0.79 0.64|
|Serum BNP||≥ 100 pg/mL||10||93%||66%||2.7||0.11|
*Diagnostic terms defined in Glossary. BNP = B-type natriuretic peptide.
Patients with acute dyspnea present clinicians with an urgent and often difficult diagnostic challenge. The initial treatments for the alternative diagnoses differ and must usually be started before definitive test results are known. In this well-reported systematic review, Wang and colleagues identified studies of reasonable quality evaluating the accuracy of the clinical findings and simple tests that most clinicians actually use to confirm or exclude HF. To maximize the usefulness of this review, clinicians must consider the LRs associated with the presence or absence of each criterion in relation to the importance they currently place on that criterion in this setting and revise their diagnostic heuristics accordingly.
Some of the findings of this review fit conventional wisdom. Elements of the history of the present illness, previous history, and electrocardiographic findings are not as strong as radiographic findings for ruling in HF, while selected physical findings are of intermediate diagnostic strength. The LR reported by Wang and colleagues for overall clinical judgment reflects awareness of chest radiography results and would probably be closer to 1 in its absence. Presence of a third heart sound, although a strong predictor, may be difficult to detect in a noisy ED. When uncertain, clinicians might pay more attention to jugular venous distention to help rule in HF. Surprisingly, the presence of dyspnea on exertion has little effect on raising the likelihood of HF, although as expected, its absence lowers HF likelihood. The diagnostic irrelevance of a history of chronic lung disease is also unexpected.
Among the criteria reported by Wang and colleagues, only a B-type natriuretic peptide level < 100 pg/mL has more than a modest effect in decreasing the likelihood of HF. The reported −LR is consistent with those of other analyses, but its effect may be inflated by the use of fixed cutoffs in the primary studies (1). Such promising tests as abdominojugular reflex and new T-wave changes on electrocardiogram require further study.
Peter C. Wyer, MD
Columbia University College of Physicians and Surgeons
New York New York, USA